Opiate for the Masses was founded in 1999 by singer [a1289966], drummer [a1289965], guitarist/keyboardist [a723952], and guitarist [a1289967]. The group's name is an alteration of Karl Marx's famous aphorism, "Religion is the opium of the people". Opiate for the Masses self-released a demo album entitled "New Machines and the Wasted Life" in 2000. In 2005, the band signed with Warcon label and issued the album "The Spore". By this time the group had added [a1369465] on drums and [a573521] on bass. In 2008, the group signed with undefined label and released the album "Manifesto". In 2009, the group disbanded.
In 2010, original band members played a reunion show to a sold out crowd in Tempe, Arizona.