Lanegan began his musical career in 1984 as the frontman of the psychedelic grunge band Screaming Trees. Following the end of Screaming Trees, he became a frequent collaborator of Queens Of The Stone Age.
Lanegan also collaborated with various artists throughout his career, including Kurt Cobain, Isobel Campbell, Moby, [a=Unkle], [a=Soulsavers] and Not Waving.